Description

Human Growth Hormone Australia

Human growth hormone supplements(Increlex 40mg/4ml)

Increlex (mecasermin) is a synthetic form of insulin-like growth factor-1 (IGF-1), used primarily to treat growth failure in children with severe primary IGF-1 deficiency. Here’s a detailed overview:

### **Overview of Increlex**

1. **Chemical Structure**:
– **Mecasermin**: Recombinant human insulin-like growth factor-1 (rhIGF-1).

2. **Typical Composition**:
– **Dosage Form**: Increlex is available as a solution for subcutaneous injection. The concentration is typically 40 mg/4 mL, which equates to 10 mg/mL.

3. **Administration**:
– **Subcutaneous Injection**: Increlex is administered via subcutaneous injection. Common injection sites include the thigh, upper arm, buttocks, or abdomen. Injection sites should be rotated to minimize the risk of local tissue damage or lipoatrophy.

4. **Dosage**:
– **Pediatric Growth Failure**:
– **Initial Dose**: Typically, the starting dose is 0.04 to 0.08 mg/kg of body weight twice daily.
– **Adjustments**: Dosage can be gradually increased based on the patient’s response and tolerance, up to a maximum of 0.12 mg/kg twice daily.

5. **Benefits**:
– **Growth Promotion**: Helps children with severe primary IGF-1 deficiency achieve normal growth.
– **Improved Growth Velocity**: Increases the rate of growth in children with IGF-1 deficiency.

6. **Side Effects**:
– **Common Side Effects**: Injection site reactions, hypoglycemia (low blood sugar), headache, dizziness, and tonsillar hypertrophy (enlarged tonsils).
– **Serious Side Effects**: Severe hypoglycemia, intracranial hypertension (increased pressure in the brain), and hypersensitivity reactions.
– **Other Considerations**: Potential risk of malignancy due to the growth-promoting effects of IGF-1.

7. **Cycle Use**:
– **Medical Use**: Increlex is used long-term as part of a treatment plan for children with severe primary IGF-1 deficiency. Treatment duration and dosage are carefully monitored and adjusted based on the patient’s growth response and side effects.

8. **Legality**:
– **Prescription Medication**: Increlex is available by prescription and should be used under the supervision of a healthcare provider specializing in pediatric endocrinology.

9. **Medical Use**:
– **Severe Primary IGF-1 Deficiency**: Used to treat children with growth failure due to severe primary IGF-1 deficiency, which is not due to growth hormone deficiency and cannot be treated with growth hormone alone.

10. **Important Considerations**:
– **Regular Monitoring**: Essential for regular monitoring of growth, blood sugar levels, and potential side effects to ensure the safety and effectiveness of the treatment.
– **Proper Injection Techniques**: Adhering to correct injection procedures is crucial to minimize risks and side effects.
– **Individual Response**: Dosage and treatment plans should be tailored to the individual’s response and growth needs.
– **Consultation**: Always consult with a healthcare professional before starting Increlex to understand potential risks and ensure appropriate use.

### Conclusion

Increlex (mecasermin) is a synthetic form of IGF-1 used to treat growth failure in children with severe primary IGF-1 deficiency. It is administered via subcutaneous injection, with dosages adjusted based on individual response and growth needs. Proper administration, monitoring, and consultation with a healthcare provider are essential for maximizing its benefits and minimizing potential side effects.